Review Note
Last Update: 10/21/2023 10:11 PM
Current Deck: All Exams P1::Pharm116 Exam#2::Handout 2
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Malate-Aspartate Shuttle (heart, liver, kidney cells)
- {{c1::Malate dehydrogenase}} regenerates NAD+ by adding {{c2::H from NADH to Oxaloacetate → Malate (reversible reaction in mitochondrial matrix)}}
- Malate moves from {{c3::cytosol}} through protein transport into {{c3::mitochondrial matrix → Oxaloacetate + NADH}}
- Glutamate (Oxaloacetate) become {{c4::Aspartate (keto acid)}} using {{c4::aspartate aminotransferase}}
- Aspartate moves from {{c5::mitochondria to cytoplasm → reverse reaction to remake oxaloacetate → cycle continues}}
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