Review Note

Last Update: 10/22/2023 09:22 PM

Current Deck: All Exams P1::Pharm116 Exam#2::Handout 3

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Reaction 1: Citrate Synthase (Oxaloacetate 4C + Acetyl CoA 2C → Citrate 6C)  
  • {{c1::Syntase}} make something {{c2::w/o ATP}}, {{c1::Synthetase}} make something {{c2::w/ high energy bond }}
  • Induced Fit: {{c3::Oxaloacetate}} binds first to change conformation → allows {{c3::Acetyl CoA to bind too }}
  • Mechanism: {{c4::General acid + base }}
  • {{c4::Close proximity and orientation}} 
  • Nu attack of {{c5::Acetyl-CoA enolate on oxaloacetate}} → {{c5::citryl CoA}} 
  • {{c6::Citryl CoA hydrolysis of  bond (-30.5kJ)}} that drives reaction forward (irreversible) → Citrate 
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