Review Note
Last Update: 01/11/2024 07:06 PM
Current Deck: PCP::PARA1200::Module 9
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Salbutamol: dosing/MOA/Pharmakinetics/other notes
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Adult dosing:
- 5 mg nebulized; repeat doses back to back as necessary
- 4 x 100 mcg via metered dose inhaler with spacer; repeat as required
- MDI and spacer use is strongly recommended for patients with signs of influenza-like illness, or other infectious respiratory conditions
Pediatric dosing:
- Via nebulizer
- Age < 1 year: 2.5 mg
- Age ≥ 1 year: 5 mg
- NB: nebulized medication therapy not authorized during Covid
- Via metered dose inhaler
- < 10 kg: not indicated
- 10-20 kg: 5 x 100 mcg per course; may repeat up to 3 times
- > 20 kg: 10 x 100 mcg per course; may repeat up to 3 times
MOA: Salbutamol is a selective beta-2 adrenergic agonist that produces bronchodilation and some degree of vasodilation. Some beta-1 effects can be seen, particularly at higher doses.
Pharmacokinetics:
Inhaled:
- Onset: 5-15 minutes
- Peak: 60-90 minutes
- Duration: 3-6 hours
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