Review Note

Last Update: 01/14/2024 12:31 PM

Current Deck: ✪ YEAR 1::★ 2nd Bimonthly::✦ Exam #2: The Immune System, Blood Groups, & Hemostasis::♠ Buddycards: Module 5 SGD Parts 3 & 4::🏃 Javier::✪ CU

Published

Fields:

Front
In a patient with Hemophilia C, the bleeding manifestations would result due to inactivation of which clotting
factor?

A. VIII
B. IX
C. V
D. XI
Back
B. IX

Answer: B
Rationale:
Hemophilia C is caused by the deficiency of Factor XI.
However, the question asks what this Factor XI
deficiency inactivates what clotting factor and actually
causes the bleeding manifestations. It should not be
Factor XI but the step that directly after it which it’s
deficiency causes inactivation in the cascade. Based
on the coagulation cascade, Factor XIa (activated form
of XI) activates Factor IX. Therefore, deficiency in
factor XI in Hemophilia C directly inactivates factor IX
which manifests as bleeding.
Factor XI or Anti-Hemophilic Factor C is the clotting
factor that is deficient in Hemophilia C. But the
question asked not about what is “deficit” but
“activation of what factor will be impaired”.
Factor 11a activates Factor 9. And since Hemophilia C
is the absence of Factor 11 then factor 9 will not be
activated.

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