Review Note
Last Update: 02/14/2024 07:00 PM
Current Deck: Immuno 2
Published
Fields:
Front
IgM and IgA multimers
Back
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– IgM and IgA constant regions contain a tailpiece of 18 amino acids that contain a cysteine residue essential for polymerization
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– An additional separate 15 kDa polypeptide chain called the J chain promotes polymerization by linking to the cysteines of the tailpeice
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– IgM can form PENTAMERS
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– IgA can form DIMERS; polymerization is required for transport through epithelia
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– Polymerization of Ig is thought to be important in the binding of repetitive epitopes
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