Review Note

Last Update: 02/18/2024 05:30 AM

Current Deck: Part 2::1. Subsites::CNS::Pituitary tumours

Published

Fields:

Front
CNS | Pituitary tumours | 1.5.2 | Pathology | Pituitary carcinoma
Back
  • Definition: Histologically identical to pituitary adenoma. Defined as tumours that have metastasized
  • Epidemiology
    • I: Rare!! (0.5% of pituitary tumours)
    • A: 4th - 6th decades
    • S: M=F
  • Risk factors
    • Pituitary adenoma
  • Biologic behaviour
    • G: Progression form adenoma; latency varies from 4 months to 18 years
    • P: Often locally invasive
    • N: - 
    • M: Intracranial metastases present  by definition
    • Prognosis: Poor. Median survival 12 months
    • R:
      • May be refractory to medical treatment
      • Chemotherapy trialled: temozolomide, CCNU with varying results
    • Highly aggressive
  • Microscopic appearance
    • Identical to pituitary adenoma
  • IHC:
    • Elevated Ki67 index
  • Molecular
    • P53 (100% cf. 7% in adenomas)

Further information, not for memorising (no card)
Exam

Suggested Changes:

Deck Changes (Suggestion to move the Note to the following Deck):

Field Changes:

Tag Changes: