Review Note

Last Update: 02/18/2024 05:30 AM

Current Deck: Part 2::6. High Yield Questions::Paeds

Published

List the adverse prognostic factors for Neuroblastoma. (2)

Age: children <18 months have better prognosis
Histological subtype/differentiation: undifferentiated subtype carries worse prognosis than differentiating or poorly differentiated
Stage: earlier stage of disease carries better prognosis
DNA index: hyperdiploid status carries better prognosis, particularly in those <2 years of age
MYCN gene amplifications: lower copy number of MYCN oncogene associated with better prognosis
Chromosomal alterations: 1p deletions, 11q deletions or 17q gain can confer worse prognosis

**or use patient, tumour, traetment factors to cover all bases

Shimada: favourable vs unfavourable histology (MADS)
Mitosis
Age > 18months
Differentiation
Stroma (more=better)