Review Note

Last Update: 03/17/2024 03:28 AM

Current Deck: BIOL2200 - Organelles (ER)

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Front

Explain glycosylation in terms of ER modification.

Back

function: aids in P folding + determines P function (PTM)

many secreted and plasma mem Ps are sugar-modified = glycoproteins

process: glucose precusor catalyzed by glycosyltransferases --> glycans (chain of sugars) then transfered onto Ps

- glycans can be further modified after initial transfer

e.g. hemagglutinin (quarternary structure with homotrimer) optimizes the free-floating oligosaccharide precursor which binds to the synthesized peptide via oligasaccharyl transferase (while translation is ongoing)

- chaperones/oligosaccharide-binding Ps attach onto this complex to prevent premature/incorrect folding

- disulfide isomerase promotes S-S bond formation

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