Review Note

Last Update: 05/10/2024 06:18 PM

Current Deck: Geneeskunde::2e bachelor::metabolisme en endocrinologie::Farmaco deel 1

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What is the net effect of FGF23?
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FGF23 (fibroblast growth factor 23) inhibits VitD production: The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by osteocytes in response to increased calcitriol (vit D).
- FGF23 acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule à Thus, FGF23 excretion of phosphate.
- FGF23 may also suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption

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