Review Note
Last Update: 05/10/2024 06:18 PM
Current Deck: Geneeskunde::2e bachelor::metabolisme en endocrinologie::Farmaco deel 1
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What is the net effect of FGF23?
Back
FGF23
(fibroblast growth factor 23) inhibits VitD production: The
main function of FGF23 seems to be regulation of phosphate concentration in
plasma. FGF23 is secreted by osteocytes in
response to increased calcitriol
(vit D).
- FGF23
acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate
cotransporter in
the proximal tubule à
Thus, FGF23 ↑ excretion of phosphate.
- FGF23
may also suppress 1-alpha-hydroxylase,
reducing its ability to activate vitamin D and
subsequently impairing calcium absorption
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