Review Note

Last Update: 05/18/2024 08:19 PM

Current Deck: Clin Med::MSK::Gout and pseudogout

New Card (Unpublished)

No published tags.

Is gout more commonly the result of the underexcretion or overproduction of uric acid?

Gout is caused by underexcretion of uric acid in 90% of cases

Renal underexcretion of urate in 90% of cases

Overproduction of urate in 10% of cases

There is often an overlap of both

Causes of underexcretion: idiopathic, CKD, obesity, HTN, low dose ASA, alcohol, diuretics

Causes of overproduction: idiopathic, inherited enzyme defects, certain heme/lymph dz, purine-rich diet.