Review Note

Last Update: 06/02/2024 07:25 PM

Current Deck: SLS Cards::6. Mood disorders

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What are the class, mechanisms, indications, and potential side effects of trazadone?
Seratonin antagonist and reuptake inhibitor
Mechanism: inhibits serotonin transporter, serotonin type 2 receptor, histamine and alpha-1 adrenergic receptors. Induces significant changes in 5-HT presynaptic adrenoreceptors.
Indications: MDD. (Off label: sleep, anxiety, Alzheimer disease, substance use, bulimia, fibromyalgia, PTSD, OSA)
S/e: Headaches, fatigue, lightheadedness, somnolence