Review Note
Last Update: 06/04/2024 11:43 PM
Current Deck: SLS Cards::7. Dyspnea/ cough - respiratory
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Commit #105977
What is the mechanism of action of salbutamol? What about prednisone? And spiriva?
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Commit #105977
Salbutamol
Short acting beta agonist. Binds to beta2 adrenergic receptors --> stimulate --> relax bronchial smooth muscle
Prednisone
Cortisol analogue.
Short acting beta agonist. Binds to beta2 adrenergic receptors --> stimulate --> relax bronchial smooth muscle
Prednisone
Cortisol analogue.
- Anti-inflammatory with some mineralocorticoid properties
- Stabilizes leukocyte lysosomal membranes --> prevents release of acid hydrolases from leukocytes + reduces leukocyte adhesion to capillary endothelium
- Inhibits macrophage accumulation in inflamed areas
- Reduces capillary wall permeability and edema
- Antagonizes histamine activity and release of kinin from substrates
- Reduces fibroblast proliferation, collage deposition --> decreasing scar tissue formation
- Stimulates erythroid cells of bone marrow, prolongs survival time of erythrocytes and platelets; neutrophilia and eosinopenia
- Promotes gluconeogensis, redistribution of fat from peripheral to central areas; protein catabolism
- Reduces intestinal absorption and increases renal excretion of calcium
- Suppresses immune response by reducing activity and volume of lymphatic --> lymphocytopenia
- Decreases immunoglobulin and complement concetrations + passage of immune complexes through basement membranes
- Depresses reactivity of tissue to antigen-antibody interactions
Spiriva (tiotropium)
Competitively and reversibly inhibits acetylcholine and other cholinergic stimuli at M3 receptors in smooth muscle of resp tract --> bronchodilation (LAMA)