Review Note

"Kayexalate" is a brand name. The generic name is polystyrene sulfonate. Essentially a potassium binder that prevents its absorption through the bowel. Obviously, this is NOT a rapid acting method to lower potassium levels.

Polystyrene sulfonates release sodium or calcium ions in the stomach in exchange for hydrogen ions. When the resin reaches the large intestine the hydrogen ions are exchanged for free potassium ions; the resin is then eliminated in the feces. The net effect is lowering the amount of potassium available for absorption into the blood and increasing the amount that is excreted via the feces. The effect is a reduction of potassium levels in the body.

Works great as a diuretic to reduce potassium in patients who are anuric and thus loop/thiazides won't lower potassium