Review Note
Last Update: 07/22/2024 01:49 PM
Current Deck: C2P
Published
Fields:
Front
How does lysosomal function cause lysosomal storage diseases, generally?
Back
Cytotoxicity hypothesis: diseases
are typically caused by the deficiency of one lysosomal acid hydrolase &
accumulation of a single major substrate, normally degraded by that enzyme --> causes builds up and overwhelms the endosomal/lysosomal system --> cells die
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