Review Note
Last Update: 07/22/2024 01:49 PM
Current Deck: C2P
PublishedCurrently Published Content
Front
Discuss the current
theories of the pathophysiology of Huntington’s disease.
Back
mHTT = misfolded huntintin protein
mHTT disrupts synaptic transmission and plasticity
mHTT aggregate to form intracellular inclusions that are toxic to neurons
mHTT impairs mitochondrial function which impact neurons most due to their high energy dependence
mHTT affects the ubiquitin proteosome system leading to accumulation of damaged protein, cellular stress, and toxicity
mHTT disrupts synaptic transmission and plasticity
mHTT aggregate to form intracellular inclusions that are toxic to neurons
mHTT impairs mitochondrial function which impact neurons most due to their high energy dependence
mHTT affects the ubiquitin proteosome system leading to accumulation of damaged protein, cellular stress, and toxicity
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