Review Note
Last Update: 07/22/2024 01:49 PM
Current Deck: C2P
Published
Fields:
Front
Describe
the activation of heterotrimeric G-proteins by G-Protein Coupled Receptors
(GPCRs).
Back
Ligation
of receptor (R) --> GDP -> GTP and conformational change in Ga --> decreased
affinity for R and bg-subunits
-> dissociation of receptor-G protein complex
Activated
Ga
(GTP-bound or the released bg-subunits
can interact w effectors (usually activating adenylate cyclase to convert ATP
to cAMP)-> intracellular secondary messengers
activation of downstream signaling cascades
Termination
of Signaling occurs via intrinsic GTPase activity of a-subunit
which hydrolyzes GTP -> GDP -> reassociation of the inactive G-protein
Suggested Changes:
Deck Changes (Suggestion to move the Note to the following Deck):
Field Changes:
Tag Changes: