Review Note
Last Update: 07/22/2024 01:49 PM
Current Deck: C2P
Published
Fields:
Front
Describe
HER2 (human
epidermal growth factor receptor 2) as example of a receptor tyrosine
kinase causing cancer.
Back
HER2
overexpressed --> ligands easily bind --> protein overexpression
Other ways:
o
Mutation --> inability to shut down signal
o
Mutation in
active site or kinase --> HER2 is always active --> always phosphorylating
o
Mutation of RAS -->won’t let go of GTP until it hydrolyzes by
itself --> longer activation time
o
Mutation/deletion/loss
of phosphatase --> less efficient in turning off signal (b/c
phosphates aren’t taken off)
o
Mutation in receptor
or active site --> stronger interaction --> continual activation
o
Enzymatic
cleavage of HER2 permanent activation of cytoplasmic side (don’t
need ligands)
Suggested Changes:
Deck Changes (Suggestion to move the Note to the following Deck):
Field Changes:
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