Review Note
Last Update: 07/28/2024 06:33 PM
Current Deck: Block I::Quiz 2::Week 3::e. Protein Trafficking: Endoplasmic Reticulum, Vesicular Transport, Golgi, and Exocytosis
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Front
One of the most common mutations in CFTR gene is deletion of F508. This results in CFTR protein that is... In contrast the G551D mutation allows the protein to reach the membrane to act as a transmembrane protein but it abolishes ATP-dependent gating, resulting in an open probability that is approximately 100-fold lower than that of wild-type channels.
Back
Misfolded and mistargeted in the cell so that it does not get to the plasma membrane.
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