Review Note
Last Update: 08/02/2024 01:42 AM
Current Deck: cardiac 1
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Pathophysiology of Ischemic heart disease /
coronary artery disease (CAD)
coronary artery disease (CAD)
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• When myocardial O2 demand > supply
• Atherosclerosis: cholesterol deposits beneath
vascular endothelium → calcification →plaques that obstruct blood flow
o Plaques can lead to a clot (thrombus) that occludes the artery
o Plaques can rupture (break away) and flow until they block the artery (coronary embolus)
o Plaques can irritate vascular wall →
vasospasm (wall contraction)
• Atherosclerosis: cholesterol deposits beneath
vascular endothelium → calcification →plaques that obstruct blood flow
o Plaques can lead to a clot (thrombus) that occludes the artery
o Plaques can rupture (break away) and flow until they block the artery (coronary embolus)
o Plaques can irritate vascular wall →
vasospasm (wall contraction)
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