Review Note
Last Update: 08/24/2024 12:55 AM
Current Deck: 6108::Pharmacology
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Equilibrium reaction is influenced by:
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- Affinity:
- This level determines the rate of the drug from its plasma protein. The stronger the affinity, the less likely it will dissociate. And vice versa.
- Rate of dissociation
- Pathological conditions (gut, liver)
Every drug has a different level of affinity (attraction) for its plasma protein, which determines the rate of dissociation of the drug from its plasma protein). If a drug is excreted from a body, and the free portion is DECREASING, more free drug will dissociate from the protein complex to maintain the reaction at all times.There are also certain pathological or disease states that can occur that can affect this process:.
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