Review Note
Last Update: 08/27/2024 02:41 AM
Current Deck: Temple ACMS::Pharmacology::Trey Exam 1
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A patient enters the emergency room having taken an overdose of phenobarbital. The drug is a weak acid with a pKa=7.2.
The pH of his urine is 5.2. How much of the drug is excreted vs reabsorbed?
The pH of his urine is 5.2. How much of the drug is excreted vs reabsorbed?
Back
1% is excreted
pKa - pH = log HA/A-
7.2 - 5.2 = log HA/A-
2 = log HA/A-
102 = 100 = HA/A-
HA/A- = 100/1 --> A- = 1%
pKa - pH = log HA/A-
7.2 - 5.2 = log HA/A-
2 = log HA/A-
102 = 100 = HA/A-
HA/A- = 100/1 --> A- = 1%
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