Review Note
Last Update: 09/10/2024 11:20 PM
Current Deck: MCPAP::Didactic - P2::Pathophizzz::Exam 1
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Hepatotoxic unconjugated (free) NAPQI accumulation occurs with:
1. {{c4::Excess intake of acetaminophen }}(most important)
2. {{c3::Decreased conjugation to sulfate and glucuronide}}
3. {{c2::Excessive activity (induction) of the cytochrome P450 system}}
4. {{c1::Depletion of glutathione (GSH) stores}}
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