Review Note

Last Update: 09/12/2024 09:13 AM

Current Deck: 1_Medicine::2BA_ET::01 CVC::Pharmacologie::AINS, Paracetamol, Desinfectants

Published

Fields:

Text
{{c1::5}}-{{c1::10}}% du Paracetamol est metabolisé en {{c2::N-acetyl-p-benzoquinoneimine}} ({{c2::NAPQI}}) (ULTRA toxique ⇒ {{c5::Necrose Hepatique}}) par {{c4::la CYP2E1}}
Ceci est normalement detoxifié en le conjugant avec du {{c3::Glutathion}} pour en faire du {{c3::S-Glutathione}}
Back Extra

En cas de Surdosage de Paracetamol, le Glutathion viens a manquer, dans quel cas il faut absolument prescrire de l’Acetyl Cysteine NAC (Solmucol, IV pour eviter le vomissement) qui augemnte la concentration intracellulaire de Glutathion

It is most effective in preventing or lessening hepatic injury when administered within 8–10 hours after overdose. Research suggests that the rate of liver toxicity is approximately 3% when acetylcysteine is administered within 10 hours of overdose

Tags:

Drugs::Acetylcysteine Drugs::Paracetamol Pathologies::Specific::Digestive::Liver_Diseases::Acetaminophen_Overdose

Suggested Changes:

Deck Changes (Suggestion to move the Note to the following Deck):

Field Changes:

Tag Changes: