Review Note
Last Update: 09/27/2024 07:01 AM
Current Deck: PGY 2 Path Review::Exam 1: Oct 25::Pathoma::01 The Cell
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Front
When does apoptosis occur in aberrant T cell maturation?
Back
Negative selection in the thymus, which assesses whether or not the T cell binds too avidly to self-Ag.
If it does, FAS ligand is expressed, binds FAS death receptor, apoptosis.
Positive selection, on the other hand, tests to make sure that the T cell can properly bind self-Ag on MHC.
+selection: do you bind?
+selection: do you bind?
-selection: do you bind too strongly?
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