Review Note
Last Update: 10/08/2024 02:59 PM
Current Deck: Genes and Development::Week 3::LE024 Platelet Disorders
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{{c1::Aspirin-like platelet defects}}
- Presentation:
- Platelet aggregometry: impaired platelet response to arachidonic acid and ADP
- Genetics: defect in cyclooxygenase or thromboxane synthase
- Mechanism: ↓ cyclooxygenase or thromboxane synthase activity → ↓ arachidonic acid to thromboxane A2 conversion → ↓ platelet activation amplification and ↓ platelet recruitment
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