Review Note
Last Update: 10/09/2024 02:42 PM
Current Deck: Pharmacology 2::Thrombosis & Haemostasis
PublishedCurrently Published Content
Front
Describe mechanism of action of antiplatelets (4)
Back
inhibition of platelet aggregation
MoA: acts on platelet directly
Aspirin: irreversibly blocks COX-1; inhibiting the formation of thromboxane and release of TXA2 (hence prevents further release of plateletes)
Clopidogrel: binds and blocks P2Y12 receptor preventing ADP from binding and release of fibrinogen. They prevent platelet aggregation.
3rd MoA: binding of drug to GPIIb/IIIa receptor and inhibiting the release of fibrinogen. Preventing platelet aggregation
4th MoA: phsophodoiesterterase inhibitors; the enzyme's deactivation inhibts the conversion of cAMP to AMP; decreases Ca levels in cell, causing vasodilation
MoA: acts on platelet directly
Aspirin: irreversibly blocks COX-1; inhibiting the formation of thromboxane and release of TXA2 (hence prevents further release of plateletes)
Clopidogrel: binds and blocks P2Y12 receptor preventing ADP from binding and release of fibrinogen. They prevent platelet aggregation.
3rd MoA: binding of drug to GPIIb/IIIa receptor and inhibiting the release of fibrinogen. Preventing platelet aggregation
4th MoA: phsophodoiesterterase inhibitors; the enzyme's deactivation inhibts the conversion of cAMP to AMP; decreases Ca levels in cell, causing vasodilation
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