Review Note

Last Update: 10/21/2024 03:14 PM

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A certain metabolic pathway can be diagrammed as below, where A, B, C, and D are metabolites and X, Y, and Z are the enzymes that catalyze the reactions. The free energy changes (ΔG°') for each reaction are given below the reaction arrows. Select the FALSE statement about this pathway.
A [X] → B (−0.3kJ/mol)
B [Y] → C (−12.6kJ/mol)
C [Z] → D (−1.0kJ/mol)
  • A) The major regulatory point for the pathway is enzyme Y.
  • B) If an inhibitor blocks the function of enzyme Z, the concentration of metabolite D will decrease.
  • C) If an inhibitor blocks the function of enzyme Z, the concentration of metabolite C will increase.
  • D) If an inhibitor blocks the function of enzyme Z, the concentration of metabolite B will increase.
  • E) The reaction catalyzed by enzyme X is close to equilibrium.
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D) If an inhibitor blocks the function of enzyme Z, the concentration of metabolite B will increase.

This statement is false because blocking enzyme Z would lead to an accumulation of metabolite C, not B. The concentration of B would not be directly affected by inhibiting enzyme Z.

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e4561a03-87ea-4630-b39a-e073d1995e9d

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