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Last Update: 11/20/2024 11:40 AM

Current Deck: MBBS IASM M30_Jaden:)::PP Sorted by Block_Jaden (1-44)

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Question 10

Warfarin is an anticoagulant with a narrow therapeutic index. In order to prevent over anticoagulation for people with genetic polymorphisms such as CYP2C9 and VKORC1, the dosage of warfarin should be adjusted. Which of the following concerning warfarin dosage is correct?

A. Patients carrying CYP2C9*1 and VKORC1*B haplotype require a higher maintenance dose

B. Patients carrying CYP2C9*2 and CYP2C9*3 require a higher maintenance dose

C. Patients carrying CYP2C9*2 and CYP2C9*3 require a lower maintenance dose

D. Patients carrying VKORC1*A haplotype do not need alterations in dose

E. Patients carrying VKORC1*B haplotype require a higher maintenance dosee

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