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Current Deck: Geneeskunde::3e bachelor::Nier en spijs::ZSO 32: Nierfarmacologie::Shanna's Snelweg naar Succes
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Question
Commit #268356
A patient is admitted to the emergency department with severe
tachycardia after a drug overdose. His family reports that he has
been depressed about his hypertension. Which one of the follow
ing drugs increases the heart rate in a dose-dependent manner?
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Commit #268356
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(A) Captopril
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(B) Hydrochlorothiazide
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(C) Losartan
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(D) Minoxidil
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(E) Verapamil
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Commit #268356
ACE inhibitors (choice A), ARBs (choice C), and diuretics
(choice B) do not significantly increase heart rate. Although
dihydropyridine calcium channel blockers do not usually
reduce rate markedly (and may increase it), verapamil (choice
E) and diltiazem do inhibit the sinoatrial node and predict
ably decrease rate. Other direct vasodilators (choice D) reg
ularly inmase heart rate, and minoxidil, a very efficacious
vasodilator, may cause severe tachycardia that must be con
trolled with ~ blockers. The answer is D.