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A 73-year-old man with a history of a recent change in his treatment for moderately severe hypertension is brought to the emergency department because of a fall at home. Which of the following drug groups is most likely to cause postural hypotension and thus an increased risk of falls?
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(A) ACE inhibitors
(B) Alpha1-selective receptor blockers
(C) Arteriolar dilators
(D) Beta1-selective receptor blockers
(E) Calcium channel blockers
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Drug-induced postural (orthostatic) hypotension is usually due to venous pooling or excessive diuresis and inadequate blood volume. Venous pooling is normally prevented by a-receptor activation in vascular smooth muscle; thus, ortho static hypotension may be caused or exacerbated by