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Last Update: 01/24/2025 08:27 AM

Current Deck: Geneeskunde::3e bachelor::Nier en spijs::ZSO 32: Nierfarmacologie::Shanna's Snelweg naar Succes

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Commit #268356

A patient with hypertension and angina is referred for treat ment. Metoprolol and verapamil are among the drugs con sidered. Both metoprolol and verapamil are associated with which one of the following?

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(A) Diarrhea

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(B) Hypoglycemia

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(D) Tachycardia

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(E) Thyrotoxicosis

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Commit #268356

Neither P blockers nor calcium channel blockers cause diar rhea. Hypoglycemia is not a common effect of any of the antihypertensive drugs. Thyroid disorders are not associated with either drug group. However, calcium blockers, especially verapamil and diltiazem, and P blockers are associated with depression of calcium-dependent processes in the heart, fur example, contractility, heart rate, and atriovcntricular con duction. Therefore, bradycardia and increased PR interval may be expected. In contrast to verapamil and diltiazem, dihydropyridines do not often cause cardiac depression, prob ably because they evoke increased sympathetic outflow as a result of their dominant vascular effects. The answer is C.