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Last Update: 01/24/2025 08:27 AM
Current Deck: Geneeskunde::3e bachelor::Nier en spijs::ZSO 32: Nierfarmacologie::Shanna's Snelweg naar Succes
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Question
Commit #268356
A 50-year-old man has a history of frequent episodes of renal
colic with calcium-containing renal stones. A careful workup
indicates that he has a defect in proximal tubular calcium
reabsorption, which results in high concentrations of calcium
salts in the tubular urine. The most useful diuretic agent in
the treatment of recurrent calcium stones is
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(A) Chlorthalidone
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(B) Diazoxide
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(C) Ethacrynic acid
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(D) Mannitol
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(E) Spironolactone
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Katzung
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Commit #268356
The thiazides are useful in the prevention of calcium stones
because these drugs reduce tubular calcium concentration,
probably by increasing passive proximal tubular and distal
convoluted tubule reabsorption of calcium. In contrast, the
loop agents (choice C) facilitate calcium excretion. Diazoxide
is a thiazide-like vasodilator drug but has no diuretic action;
in fact, it may cause sodium retention. It is used in hyperten
sion and insulinoma (see Chapter 11). The answer is A