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Which of the following is an important effect of chronic ther apy with loop diuretics?
QType (0=kprim,1=mc,2=sc)
Commit #268356
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(A) Decreased urinary excretion of calcium
(B) Elevation of blood pressure
(C) Elevation of pulmonary vascular pressure
(D) Metabolic alkalosis
(E) Teratogenic action in pregnancy
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Katzung
Loop diuretics increase urinary calcium excretion and tkcrease blood pressure (in hypertension) and pulmonary vascular pressure (in congestive heart failure). They have no recognized teratogenic action. They cause metabolic alkalosis (Table 15-1). Loop diuretics also cause ototoxicity. The answer is D.