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Last Update: 01/24/2025 08:27 AM
Current Deck: Geneeskunde::3e bachelor::Nier en spijs::ZSO 32: Nierfarmacologie::Shanna's Snelweg naar Succes
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Question
Commit #268356
A 62-year-old man with advanced prostate cancer is admit
ted to the emergency department with mental obtundation.
An electrolyte panel shows a serum calcium of 16.5 (normal
8.5-10.5 mg/dL). Which of the following therapies would be
most useful in the management of severe hypercalccmia?
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Commit #268356
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(A) Acetazolamide plus saline infusion
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(B) Furosemide plus saline infusion
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(C) Hydrochlorothiazide plus saline infusion
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(D) Mannitol plus saline infusion
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(E) Spironolactone plus saline infusion
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Commit #268356
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Commit #268356
Diuretic therapy of hypercalcemia requires a reduction in cal cium reabsorption in the thick ascending limb, an effect of loop diuretics. However, a loop diuretic alone would reduce blood volume around the remaining calcium so that serum calcium would not decrease appropriately. Therefore, a saline infusion should accompany the loop diuretic. The answer is B.