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Last Update: 01/24/2025 08:27 AM

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Commit #268356

A 70-year-old woman is admitted to the emergency depart ment because of a discomfort on urinating. She has had diabetes for 10 years and takes several oral medications. A finger-stick blood glucose determination is normal but uri nalysis reveals white blood cells and gram-negative rods. Which of the following drugs is the most likely cause of her infection?

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(A) Acetazolamide

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(B) Dapagliflozin

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(D) Spironolactone

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(E) T olvaptan

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Commit #268356

Diabetes is associated with increased susceptibility to infec tion. The fact that the patient has a normal blood glucose indicates that her medications are reducing blood glucose and, combined with a urinary tract infection, further suggests that urine glucose is elevated. Increased glucose excretion in the urine is an effect of the SGLT2 inhibitors. The answer is B, dapagliflozin.