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Last Update: 01/24/2025 08:27 AM
Current Deck: Geneeskunde::3e bachelor::Nier en spijs::ZSO 32: Nierfarmacologie::Shanna's Snelweg naar Succes
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Question
Commit #268356
Which of the following drugs is most likely to increase the
risk of toxicity of methotrexate, a weak acid that is primarily
cleared in the urine?
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(A) Acetaminophen
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(B) Allopurinol
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(C) Colchicine
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(D) Hydroxychloroquine
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(E) Probenecid
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Commit #268356
Like other weak acids, methotrexate depends on active tubu
lar excretion in the proximal tubule for efficient elimination.
Probenecid competes with methotrexate for binding to the
proximal tubule transporter and thereby decreases the rate of
clearance of methotrexate. The answer is E.