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Last Update: 01/24/2025 08:27 AM

Current Deck: Geneeskunde::3e bachelor::Nier en spijs::ZSO 32: Nierfarmacologie::Shanna's Snelweg naar Succes

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Question

Commit #268356

Which of the following patient characteristics is the most compelling reason for avoiding celecoxib in the treatment of her arthritis?

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Commit #268356

A 54-year-old woman presented with signs and symptoms consistent with an early stage of rheumatoid arthri tis. The decision was made to initiate NSAID therapy.

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History of alcohol abuse

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(B) History of gout

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(D) History of osteoporosis

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Commit #268356

(E) History of peptic ulcer disease

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Commit #268356

Katzung

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Commit #268356

Celecoxib is a COX-2-selective inhibitor. Although the COX-2 inhibitors have the advantage over nonselective NSAIDs of reduced gastrointestinal toxicity, clinical data suggest that they are more likely to cause arterial thrombotic events. A history of myocardial infarction would be a compel ling reason to avoid a COX-2 inhibitor. The answer is C.