Review Note

Last Update: 02/05/2025 08:20 AM

Current Deck: BPT QC

Published

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Front

A 72 year old man with a history of AF and is known to be a fast CYP2D6 metaboliser with a history of previous codeine toxicity. Which rate control agent will be expected to have an expected increased dose, given the pharmacogenetics?

A. Amiodarone

B. Metoprolol

C. Digoxin

D. Verapamil

Back

B. Metoprolol

CYP2D6 - metabolizes:

- Antidepressants (paroxetine, tricyclic antipressants)

- Beta blockers (metoprolol, bisoprolol)

- Tamoxifen

- Analgesics (tramadol, codeine)

- Antipsychotics

Tags:

#AF #Cardiology #Pharmacology

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