Review Note
Last Update: 02/05/2025 08:20 AM
Current Deck: BPT QC
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Front
Within the pancreatic beta islet cell, the sulphonylurea class of medications act upon which of the following?
A. AMP kinase enzyme
B. ATP sensitive potassium channel
C. Insulin vesicle secretion
D. Glucokinase
E. Voltage Gated Calcium Channel
Back
B. ATP sensitive potassium channel
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Mechanism of sulfonylureas
- Inhibition of ATP-sensitive potassium channels on pancreatic beta cells
- Reduces potassium efflux causing cell depolarisation
- Membrane depolarization leads to calcium channel activation and calcium influx
- Stimulation of insulin release
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