Review Note

Last Update: 02/06/2025 03:56 AM

Current Deck: STEP 1::Biochemistry::Molecular Biochemistry

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Anverso

A 65-year-old man with colorectal cancer is treated with 5-fluorouracil (5-FU). This drug primarily inhibits the conversion of:

A) dUMP to dTMP

B) IMP to AMP

C) PRPP to 5-phosphoribosylamine

D) UMP to CTP

E) Hypoxanthine to IMP

Reverso

(A) dUMP to dTMP

Explanation: 5-FU is a pyrimidine analog that inhibits thymidylate synthase, blocking the conversion of dUMP to dTMP. This depletes thymidine nucleotides, leading to impaired DNA synthesis and “thymineless death” of rapidly dividing cancer cells.

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