Review Note
Last Update: 03/27/2023 06:30 PM
Current Deck: Spring '23::Adv. Principles of Anesthesia I::Exam IV::Coagulation
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Platelets
- Normal platelet count is {{c1::150,000}} to {{c1::300,000}} platelets/mm3
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Produced in {{c1::bone marrow}} from {{c1::fragments of large cells called megakaryocytes}}
- Because platelets are {{c1::fragments}}, there is no {{c1::nucleus}} and they cannot reproduce.
- Lifespan in the circulation is {{c1::8 to 12 days}} ({{c1::1 to 2 weeks}})
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The spleen holds {{c1::1/3}} of the body’s circulating platelets.
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Cleared by {{c1::reticuloendothelial system}} ({{c1::macrophages}}) and the {{c1::spleen}}.
- {{c1::Small}} particles, {{c1::1 to 4 microns}} in diameter
- Due to their smaller size, platelets are found {{c1::near the vessel wall, closer to their site of action}}.
- Platelets circulate in {{c1::inactive form}}.
- Activated platelets perform several major tasks (3).
- {{c1::Form a temporary platelet plug}}
- {{c1::Release many potent procoagulants}}
- {{c1::Provide a meeting place for the coagulation factors to interact}}
- On the external membrane of the platelet are {{c1::glycoproteins}} and {{c1::phospholipids}}.
- {{c1::Glycoproteins}} are {{c1::repelled by intact vasculature, but adhere to injured vasculature}}.
- {{c1::Phospholipids}} act as {{c1::a substrate for prostaglandin synthesis. Prostaglandins produce thromboxane A2}}.
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