Notes in LE024 Platelet Disoders

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Published 10/08/2024 Disorders of platelet number (x2): {{c1::thrombocytopenia (low platelets), thrombocytosis}}Disorders of platelet function: {{c2::thrombasthenia }…
Published 10/08/2024 L.S.  is a 20 year-old male college student. Three weeks ago, he developed fever, sore throat, chills, and headache. He was seen at the universit…
Published 10/08/2024 Primary vs. Secondary hemostatic defects{{c1::Primary}} hemostasissuperficial (mucocutaneous bleeds)skin, mucosa, GI, genitourinaryexcessive bleeding …
Published 10/08/2024 {{c1::Thrmobocytopenia}}Platelets < 150{{c2::Mild}}: 50-100{{c3::Moderate}}: 20-50{{c4::Severe}}: <20
Published 10/08/2024 Thrombocytopenia caused by:reduced {{c1::platelet production}}can be caused by liver disease, BM, heme disordersincreased {{c2::platelet destruction}}…
Published 10/08/2024 What can cause pseudothrombocytopenia AKA artifactual thrombocytopenia detected via blood smear?
Published 10/08/2024 {{c1::Primary ITP (isolated thrombocytopenia)}} is an autoimmune disorder of thrombocytopenia in the absence of other causes or disorders that may be …
Published 10/08/2024 Pathophysiology of ITP{{c1::antiplatelet autoantibodies}}NOTE - healthy individuals without ITP also have antiplatelet autoantibodies so it's not as h…
Published 10/08/2024 Treatment of ITP:{{c2::1st}} line of therapy:{{c3::steroids}} (dexamethasone, prednisone)IV immunoglobulinRh(D) immunoglobulin (if Rh+ individual){{c1…
Published 10/08/2024 {{c1::Megakaryocytes}} are cells that produce platelets and destruction of these cells may lead to ITP (isolate thrombocytopenia)
Published 10/08/2024 L.S.  is a 20 year-old male college student. Three weeks ago, he developed fever, sore throat, chills, and headache. He was seen at the universit…
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