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[01] Immune Response
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charlie-early-fifteen-paris-beer-pennsylvania
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Published
01/08/2024
Smaller than immunogens, Incapable of evoking immune response alone unless bound to carrier
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Main function of immune system
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Molecules that evoke an immune response when introducedinto a host that recognizes them as non-self
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3 types of antigens
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Type of antigen: Coming from outside the body
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Type of antigen: From within the body
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Type of antigen: Antigens “isolated” from the immune system; When their containment is ruptured, the release of these substances incites an immune res…
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Types of Immunity
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Types of Immunity: Summation of all the naturally occurring defense mechanisms that protect the individual from infectious disease
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Types of Immunity: A specific immunologic response that occurs from exposure to a particular infectious agent
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Cardinal Features of Adaptive Immunity
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T/F: When the antigen is able to bypass the protection afforded bythe natural immune response, the adaptive immune response isrecruited
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Factors Modifying the Immune Response
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Components of Innate Immunity
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Functions of Macrophages
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Role of macrophages in the adaptive immune response is due to the presence of surface receptors for
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Definition: process of enhancing phagocytosis
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Examples of Opsonins
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Opsonins role in innate immunity
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Opsonins role in adaptive immunity
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CD (cluster differentiation) for all inflammatory cells
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CD (cluster differentiation) for B lymphocytes:
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CD (cluster differentiation) for T lymphocytes
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CD (cluster differentiation) for Natural Killer (NK) Cells
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Lymphocyte Classes
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Lymphocyte for Viral and Fungal infections
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Lymphocyte for Bacterial infections
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Surface markers of B lymphocytes
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Surface marker of T-helper
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Surface marker of T-suppressor or cytotoxic T-cell
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Roles of Helper and Cytotoxic T-cellsWhich is CD4? CD8?Effectors● Effectors for DTH ___● Effectors for cytotoxicity ___Modulators● Helper for Ab synth…
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Delayed type hypersensitivity (DTH) is the immune response typified by
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Cytotoxicity is the immune response toward
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Fill in the blanksT4 – _____________ – DTH__ – T-suppressor cells – __________
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Stages of Lymphocyte Differentiation in CMIR
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Types of Immunoglobulins
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Type of Immunoglobulins: Major immunoglobulin in normal serum
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Type of Immunoglobulins: Small enough to cross placental barrier and protect the newborn
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Type of Immunoglobulins: Plays a role in phagocytosis (opsonization), particularly with the Fc receptors on IgG
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Type of Immunoglobulins: Secretory, synthesized by epithelial cells
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Type of Immunoglobulins: Interferes with the adherence and colonization of pathogens
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Type of Immunoglobulins: Usually found in the mouth, eyes, and vagina
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Type of Immunoglobulins: Predominant antibody produced by the fetus
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Type of Immunoglobulins: Unknown function [to be updated]
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Type of Immunoglobulins: Responsible for immediate type hypersensitivity reactions (Type I hypersensitivity)
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Sites on or within the antigen that the antibody reacts with, Determines specificity
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What theory? → Currently accepted theory of antibody diversity→ Each B cell has only (1) type of Ig receptor and can only be stimulated by (1) type o…
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Renewed rapid production of an antibody following second orlater contact with the provoking antigen or with related antigens; Principle behind vaccina…
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Cell mediated or Humoral: T-lymphocytes
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Cell mediated or Humoral: Leads to to production of effector T-lymphocytes and lymphokines
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Cell mediated or Humoral: Modulated by 2 T cell types: helper and suppressor
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Cell mediated or Humoral: B-lymphocytes
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Cell mediated or Humoral: Leads to production of plasma cells that secrete antibodies
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Categories of immune system dysfunction
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Types of Hypersensitivity Disorders
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Type of Hypersensitivity Disorders: Mechanism:IgE mediated-mast cell activation & degranulationMast cells and Basophils release the following▪ Bio…
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Type of Hypersensitivity Disorders: Clinical Manifestation:→ Localized or generalized→ Occurs immediately or within minutes after exposure to an antig…
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Type of Hypersensitivity Disorders: Mechanism:→ Cytotoxic (IgM, IgG) antibodies vs. cell surface antigen→ Complement pathway usually involved
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Type II: Cytotoxic Types of Responses
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Type II: Cytotoxic Types of Responses: which type?Direct lysis of a target cell due to the activation of the complement pathway; involves membrane att…
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Type II: Cytotoxic Types of Responses: which type?Antigen-antibody complex is phagocytosed when the opsonin C3b is detected by the macrophage
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Type II: Cytotoxic Types of Responses: which type?Antigen-antibody complexes initiate the complement pathway resulting in inflammation and eventual de…
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Type II: Cytotoxic Types of Responses: which type?Antibodies bind to receptors of the body; E.g. Graves’ disease - TSH→ Brought about by the presence…
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Type II: Cytotoxic Types of Responses: which type?Involves phagocytes, NK cells, and killer T cells; Natural Killer cells recognize antigens on a cell…
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Type II vs Type III hypersensitivity
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Type of Hypersensitivity Disorders: Mechanism:→ IgM and IgG react with antigens circulating in the vascular compartment and are then deposited in tiss…
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Type of Hypersensitivity Disorders: Mechanism:→ Mononuclear cells (T cells and macrophages) produce interleukins and lymphokines→ Does not involve an…
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Examples of Congenital Immunodeficiencies
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Causes of Acquired Immunodeficiencies
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