Notes in 4 Genetics Basis for Disease

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Published	07/30/2024	Three approaches of {{c2::gene mapping}} discussed (i.e. approaches in discovering particular genes implicated in disease):{{c1::1. Linkage analysis (…
Published	07/30/2024	Linkage analysis is {{c1::family}}-based
Published	07/30/2024	Association analysis is {{c1::population}}-based
Published	07/30/2024	Linkage analysis can be used only if the disease of interest follows a {{c1::Mendelian inheritance}} pattern
Published	07/30/2024	Association analysis is used for studying {{c1::complex (multifactorial)}} diseases
Published	07/30/2024	Genome sequencing is used for studying {{c1::rare Mendelian}} diseases
Published	07/30/2024	What makes a Mendelian disorder rare?{{c1::1. Not enough families for linkage analysis can be secured2. Genetically lethal (i.e. poor genetic fitness)…
Published	07/30/2024	{{c1::Genome sequencing}} is best used in studying diseases that cannot be analyzed using {{c2::linkage analysis}}
Published	07/30/2024	{{c2::Linkage analysis}} tests only the {{c1::coinheritance}} of the disease with a particular genomic region, not the role of the marker in the disea…
Published	07/30/2024	Associational analysis may utilize 3 research designs:{{c1::1. Case-control studies2. Cross-sectional studies3. Cohort studies::3}}
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