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Nutrition II::04. Exercise Nutrition and Sports Supplements
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12/08/2023
Monozygotic Twin Study on effects of exercise:
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Muscle Contraction: The {{c1::amount, speed, and power}} you generate is a function of how quickly you generate {{c2::ATP}}
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There is an {{c1::inverse}} relationship with {{c1::ATP}} generating fuels (ie creatine phosphate, anaerobic glycolysis) and stores of mater…
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Fat makes ATP very {{c1::slowly}}
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As intensity increases, reliance on fat metabolism {{c1::decreases}} and {{c1::glucose}} increases
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We use {{c1::muscle glycogen}} as the primary source for intense exercise
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When do you burn fat for fuel?
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As you increase the intensity, your need for {{c1::ATP}} increases, need for {{c1::glucose}} increases→ use {{c1::muscle glyc…
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Muscle Glycogen does not help long during:
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Muscle will take some {{c1::glycogen}} from the liver however it’s used mostly for {{c1::blood glucose}} regulation
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There is {{c1::more}} muscle glycogen stores overall than liver glycogen stores
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For long durations of exercise we use a combination of {{c1::glucose}} and {{c1::fat}}
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Acetyl CoA from fat metabolism slows {{c1::pyruvate dehydrogenase}}, slows glycolysis → you don't burn off all of glycogen at once
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Combining ATP production depends on the size of {{c1::glycogen store}} and rate of {{c1::FA b-oxidation }}
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Why do we carb load before a workout?
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Depletion-Repletion Cycle
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There is evidence that protecting muscle glycogen by maximizing stores works and that taking {{c1::oral glucose}} supplements during exercise wor…
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Sugar water v water study:
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When is the best time to workout?
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New sports drinks have similar effects to
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Carb Rinsing:
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When combining {{c1::fat}} and {{c1::carbs}} to maximize ATP production over a long period of time, there is an advantage to increasing fat if yo…
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Respiratory exchange ratio (RER): {{c1::the ratio between the amount of oxygen consumed and carbon dioxide produced in one breath = VCO2/VO2}}RER…
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Direct relationship between {{c1::exercise}}, {{c1::protein turnover}}, and {{c1::protein synthesis }}
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Does amino acids supplementation stimulate protein synthesis?
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Protein synthesis increases from taking supplements {{c1::1-3 hours}} post exercise
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AA supplements have {{c1::not shown}} that they increase strength
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When cutting calories and taking extra protein, it protects {{c1::lean muscle loss}} from calorie restricted weight loss
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Amino acids have {{c1::endocrine}} effects, ie stimulating growth factorsInsulin is a growth factor - Leu, PheTaking these after a work out would…
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Nitric oxide - vaso{{c1::dilator}}
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If you stimulate NO with {{c1::arginine}}, you increase blood flow to peripheries, increase O2 delivery to muscles and increase performance
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Study: control diet, arginine rich diet, control + 10g arginine supplementswhat was the finding?
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When you work out, you naturally get vaso{{c1::dilation}} from {{c1::ANS}} innervationDoes Not help athletes but it helps people with {{c1::…
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SWAP- MEAT study
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SWAP-MEAT study findings:
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Creatine stores at normal conditions are about {{c1::60-80% full}}
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When you take creatine, you increase stores of {{c1::phosphocreatine}}The fastest way to make {{c1::ATP}}
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If you take creatine supplements → increase {{c1::phosphocreatine}} →burn it quickly and recover {{c1::quickly}}
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Study on Creatine and performance
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A generic term for a range of body building supplement products used by athletes and weightlifters to enhance athletic performance
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12/09/2023
Ephedra
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Ultimate orange = {{c1::first pre workout}}
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{{c1::Arginine AKG}} → contains citrulline which is an alternative route to making NO in kidneys
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{{c1::Jack3d}} - DMAA which has now been banned
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High in {{c1::caffeine}} → performance enhancing drug
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People drink {{c1::too much}} fluid, dilute their solutes → risk for {{c1::hyponatremia}} Spaced out drinking stations in marathons
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Ketogenic Hydrating agents
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Pros and Cons of working out in the morning?
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Pros and Cons of working out midday
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Pros and Cons working out at night
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Indoor v outdoor running
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Exercise is good for us for what reasons
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what are myokines
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Exercising improves memory caused by {{c1::cathepsin B}}
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Cathepsin B: Secreted from {{c1::muscle}}Influences {{c2::hippocampal}} nerve regeneration Does not improve memory if you KO cathe…
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When you exercise → {{c1::IL-6}} increase → {{c1::decreases}} visceral fat mass
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If you add Ab’s or IL6 receptor antagonists → visceral fat mass does {{c1::not decrease}}
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How does a single bout of exercise help diabetes?
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If pts can lose {{c1::10-15%}} of body weight, they will regain {{c1::glycemic control}} even if they are obese because you lose visceral fat mas…
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