Notes in dermatopathology

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Zanki Dermatology

Status	Last Update	Fields
Published	12/13/2024	Melanocytes are derived from {{c1::neural crest}} cells.
Published	12/13/2024	What is depicted by the arrow labelled 1?
Published	12/13/2024	What is a {{c1::benign proliferation of melanocytes along the dermoepidermal junction}}?{{c2::Lentigo simplex}}.
Published	12/13/2024	What is the pattern of basal cell carcinoma shown?
Published	12/13/2024	What pattern of basal cell carcinoma is shown?
Published	12/13/2024	A {{c1::compound nevus}} is a nevus with a {{c2::dermoepidermal junction and dermal component}}.
Published	12/13/2024	What is the obvious diagnosis?
Published	12/13/2024	Key microscopic features of {{c6::seborrhic keratosis}} are:1. Epidermal {{c1::acanthosis}} and {{c2::hyperkeratosis}}. 2. {{…
Published	12/13/2024	Key microscopic features of {{c1::actinic keratosis}} are:1. Focal {{c2::parakeratosis}}.2. {{c3::Keratinocytic atypia}} in deep layers of epidermis.
Published	12/13/2024	What is the most likely diagnosis based on the image?
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Seborrheic keratosis}}.
Published	12/13/2024	{{c1::Leser-Trélat}} sign is a paraneoplastic phenomenon of rapid growth of multiple {{c2::seborrheic keratoses}} associated with …
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Solar lentigo}}.
Published	12/13/2024	Skin gross finding.Most likely diagnosis?{{c1::Solar lentigo}}.
Published	12/13/2024	The key microscopic feature of solar lentigo is the {{c1::“dirty feet” or finger-like proliferation of hyperpigmented rete}} growing do…
Published	12/13/2024	Variants of squamous cell carcinoma are:1. {{c1::Keratoacanthoma}}.2. {{c2::Acantholytic}}.3. {{c3::Verrucous}}.4. {{c4::Desmoplastic}}.
Published	12/13/2024	Risk factors for metastasis of squamous cell carcinoma originating from the skin are: 1. {{c1::Location (ear, lip)}}. 2. {{c2…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Basal cell carcinoma}}.
Published	12/13/2024	Morphologic variants of basal cell carcinoma include: 1. {{c1::Nodular (large, rounded nests)}}.2. {{c2::Micronodular (smaller nests)}}.3. {{c3::…
Published	12/13/2024	A basal cell carcinoma in a child should raise concerns for {{c1::Gorlin’s}} syndrome.
Published	12/13/2024	The aggressive morphologic variants of basal cell carcinoma include:1. {{c1::Microonodular}}.2. {{c2::Infiltrative}}.3. {{c4::Sclerosing/morpheic}}.4.…
Published	12/13/2024	Skin cyst excision.Most likely diagnosis?{{c1::Epidermal inclusion cyst}}.
Published	12/13/2024	Epidermal inclusion cysts are lined by a {{c1::squamous epithelium with granular layer and containing laminated, basket weave keratin}}.
Published	12/13/2024	What is the difference between an epidermal inclusion cyst and a dermoid cyst?{{c1::- Epidermoids -> only squamous epithelium.- Dermoids ->…
Published	12/13/2024	Skin cyst excision.Most likely diagnosis?{{c1::Dermoid cyst}}.
Published	12/13/2024	Child with a skin excision.Most likely diagnosis?{{c1::Spitz nevus}}.
Published	12/13/2024	Skin excisional biopsy.Most likely diagnosis?{{c1::Compound nevus}}.
Published	12/13/2024	Signs of a benign nevus include:1. {{c1::Absence of a “shoulder” or junctional component extending past the dermal component}}.2. {{c2::Norm…
Published	12/13/2024	Skin lesion excision.Most likely diagnosis?{{c1::Neurofibroma}}.
Published	12/13/2024	Key microscopic features of a neurofibroma include:1. {{c1::Dermal lesion}} [location].2. {{c2::Delicate spindle cells (Schwann ce…
Published	12/13/2024	Immunohistochemistry that can support the diagnosis of a neurofibroma include:1. {{c1::S100(+) in ~ 50% of total cells (Schwann cells)}}.2. {{c2:…
Published	12/13/2024	Skin lesion excision.Most likely diagnosis?{{c1::Merkel cell carcinoma}}.
Published	12/13/2024	{{c1::Merkel cell carcinoma}} is a cutaneous {{c2::neuroendocrine carcinoma}} (type of cancer).
Published	12/13/2024	Merkel cell carcinomas that positive for {{c1::P63}} by immunohistochemistry have a worse prognosis.
Published	12/13/2024	The 2 growth phases of melanoma are:1. {{c1::Radial growth phase}}.2. {{c2::Vertical growth phase}}.
Published	12/13/2024	Melanoma depth of invasion is termed the {{c2::Breslow thickness}} and is measured from {{c1::granular layer}} of the epidermis to…
Published	12/13/2024	The developmental pathways of melanoma can be classifed according to:1. {{c1::Low cumulative sun damage}}.2. {{c1::High cumulative sun damage}}.3. {{c…
Published	12/13/2024	Subtypes of melanoma include:1. {{c1::Superficial spreading melanoma}}.2. {{c2::Lentigo maligna melanoma}}.3. {{c3::Acral melanoma}}.4. {{c4::Nodular …
Published	12/13/2024	The common presentation of metastatic melanoma to the skin is a {{c1::solitary pigmeneted dermal nodule}}.
Published	12/13/2024	Metastatic melanoma to the skin should be classified as either:a) {{c1::Satellite metastasis}} ({{c2::within 2 cm of primary}}).b) {{c1::In-transit me…
Published	12/13/2024	{{c1::BerEP4}} immunohistochemistry will stain basal cell carcinoma, but NOT squamous cell carcinoma.
Published	12/13/2024	Key microscopic features of a cylindroma are:1. {{c1::Basaloid nests}} of cells with a "{{c2::jig-saw}}" appearence.2. {{c4::2}} cell populations (num…
Published	12/13/2024	Skin lesion excision.Most likely diagnosis?{{c1::Cylindroma}}.
Published	12/13/2024	Skin lesion excision.Most likely diagnosis?{{c1::Pilomatrixoma}}.
Published	12/13/2024	Key microscopic features of a pilomatrixoma are:1. {{c1::Well-}}circumscribed {{c2::dermal}} lesion (location).2. {{c3::Basaloid peripheral matri…
Published	12/13/2024	A syringoma most commonly clinically presents as a {{c1::papule}} on the {{c2::cheek}} or {{c2::lower eyelid}}.
Published	12/13/2024	Key microscopic features of a {{c1::syringoma}} include:1. Small {{c3::ducts, nests, cords,}} and {{c3::cysts}} in the {{c2::superficial der…
Published	12/13/2024	Skin lesion excision.Most likely diagnosis?{{c1::Syringoma}}.
Published	12/13/2024	Skin lesion excision.Most likely diagnosis?{{c1::Chondroid syringoma}}.
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Lichen planus}}.
Published	12/13/2024	Key microscopic features of lichen planus are:1. Compact {{c7::hyperkeratosis}} without {{c7::parakeratosis}}2. Wedge-shaped {{c8::hypergranulosis}}.3…
Published	12/13/2024	What feature of lichen planus is demarcated by the black box?{{c1::Civatte bodies (degenerated keratinocytes)}}.
Published	12/13/2024	The main differential for lichen planus is {{c1::benign lichenoid keratosis}} (clinically: {{c2::single lesion on trunk}}).
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Molluscum contagiosum}}.
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Spongiotic dermatitis}}.
Published	12/13/2024	Clinically spongiotic dermatitis presents as pruritic {{c1::vesicles}}, {{c1::papules}}, and {{c1::plaques}} (essentially {{c2::ec…
Published	12/13/2024	Key microscopic features of spongiotic dermatitis include:1. {{c4::Intraepidermal intercellular edema (spongiosis)}}.2. Superficial dermal {{c3::infla…
Published	12/13/2024	Skin excision.Most likely diangosis?{{c1::Verruca vulgaris}}.
Published	12/13/2024	Verruca vulgaris mostly involves {{c1::fingers}} and {{c1::dorsal hands}} (anatomical sites), and {{c2::palms}} and&nbsp…
Published	12/13/2024	Key microscopic features of verruca vulgaris includes:1. {{c1::Mounds of parakeratosis (church spires)}}.2. {{c2::Cup-shaped papillomatosis}…
Published	12/13/2024	Verruca vulgaris is cause by the most common types of HPV including {{c1::1-4, 7, and 10}} (6 types).
Published	12/13/2024	{{c3::Condyloma acuminatum}} is an HPV-related lesion caused by types {{c1::6}} and {{c1::11}} involving the {{c2::genit…
Published	12/13/2024	Child with non-pruritic skin lesions.Most likely diagnosis?{{c1::Verruca vulgaris}}.
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Stasis dermatitis}}.
Published	12/13/2024	Key microscopic features of stasis dermatitis include:1. {{c1::Spongiotic}} dermatitis.2. {{c2::Vascular}} proliferation.3. Red blood cell {{c3::extra…
Published	12/13/2024	What stain can be helpful to support the diagnosis of stasis dermatitis?{{c1::Prussian blue iron stain positive}}.
Published	12/13/2024	Key microscopic features of dermatophytosis include:1. {{c2::Sandwich}} sign - {{c1::parakeratosis beneath basket-weave stratum corneum}}.2. {{c3::Neu…
Published	12/13/2024	Excisional shave of skin.Most likely diagnosis?{{c1::Granular cell tumor}}.
Published	12/13/2024	A granular cell tumor is a {{c1::benign}} (benign/malignant) tumor of putative {{c2::schwannian}} origin.
Published	12/13/2024	Key microscopic features of a granular cell tumor include:1. Cells with {{c1::abundant granular}} cytoplasm 2. Frequently overlyin…
Published	12/13/2024	Pseudoepitheliomatous hyperplasia found surounding a granular cell tumor must NOT be overinterpretted as {{c1::squamous cell carcinoma}}.
Published	12/13/2024	Immunohistochemistry of granular cell tumors are:1. {{c1::PAS-D}} granules (positive).2. {{c2::S100}} (positive).3. {{c3::SOX10}} (positive).4. {{c4::…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Scar}}.
Published	12/13/2024	Key microscopic features of a scar include:1. {{c1::Dense}} collagen fibers running {{c2::parallel}} to surface.2. Small {{c3::perpendicularly}} orien…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Kaposi sarcoma}}.
Published	12/13/2024	Kaposi sarcoma is a vascular neoplasm caused by {{c1::HHV-8}} and is often associated with {{c2::AIDS}}.
Published	12/13/2024	Key microscopic features of Kaposi sarcoma include:1. {{c1::Dermal spindle}} cell tumor.2. {{c4::Jagged interconnected slit-like}} vascular chann…
Published	12/13/2024	Most likely diagnosis?{{c1::Glomus tumor}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Glomus tumor}}.
Published	12/13/2024	Key microscopic features of glomus tumors are:1. {{c3::Solid nests}} of {{c3::round}} cells.2. {{c2::Uniform, central}} nuclei.3. Assoc…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Pyogenic granuloma}}.
Published	12/13/2024	Key microscopic features of a pyogenic granulmoa are:1. {{c3::Exophytic}} with {{c4::collarette}}. 2. Numerous {{c2::small capillaries}…
Published	12/13/2024	Skin excison.Most likely diagnosis?{{c1::Neurothekeoma}}.
Published	12/13/2024	Key microscopic features of a neurothekeoma are:1. {{c1::Epitheloid}} to {{c1::spindled}} cells. 2. Arranged in multiple {{c3::nests}} divided by {{c4…
Published	12/13/2024	Skin papule, punch biopsy.Most likely diagnosis?{{c1::Lymphomatoid papulosis}}.
Published	12/13/2024	Lymphomatoid papulosis clinically presents as crops of {{c1::papules}} and {{c1::nodules}} at different {{c2::stages of devel…
Published	12/13/2024	The most helpful immunohistochemistry marker for lymphomatoid papulosis is {{c1::CD30 (positive)}}.
Published	12/13/2024	Key microscopic features of lymphomatoid papulosis include:1. {{c4::Wedge}}-shaped {{c5::dermal}} lesion.2. {{c3::Atypical large}} CD{{…
Published	12/13/2024	Compared to primary systemic anaplastic large cell lymphoma, primary cutaneous anaplastic large cell lymphoma is usually {{c1::ALK negative}}&nbs…
Published	12/13/2024	For cases of primary cutaneous anaplastic large lymphoma, most malignant cells (>75%) are {{c1::CD30 positive}} (immunohistochemistry).
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Anaplastic large cell lymphoma (unable to determine cutaneous vs systemic)}}.
Published	12/13/2024	Key microscopic features of cutaneous anaplastic large cell lymphoma include:1. {{c1::Sheets}} (cellular arrangement). 2. {{c2::Large anapla…
Published	12/13/2024	Malignant cells in mycosis fungoides are CD{{c1::4 positive lymphocytes}} (cell type and immunohistochemstry).
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Mycoses fungoides}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Leiomyoma}}.
Published	12/13/2024	Clinically, {{c3::psoriasis}} may display {{c1::Auspitz sign}} of {{c2::pinpoint bleeding when scale is removed}}.
Published	12/13/2024	Histologically, {{c3::psoriasis}} may display {{c1::Munro microabscesses}} of {{c2::neutrophil collections in corneal layer}}…
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Psoriasis}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Plexiform neurofibroma}}.
Published	12/13/2024	A plexiform neurofibroma contains multiple {{c1::nodules}} of neurofibroma throughout dermis/subcutis.
Published	12/13/2024	Skin punch biopsy.Most likely diagnosis?{{c1::Pitted keratolysis (small pits in macerated stratum corneum with coccobacilli or filaments)}}.
Published	12/13/2024	Shave of skin.Most likely diagnosis?{{c1::Squamous cell carcinoma, acantholytic type}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Angioleimyoma (DDx dermatofibroma)}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Steatocystoma}} ({{c2::intradermal}} cyst lined by {{c3::squamous}} epithelium, compressed {{c3::sebaceous g…
Published	12/13/2024	Shave of skin.Most likely diagnosis?{{c1::Elastosis peforans serpiginosa (epidermal perforation with altered elastic fibers)}}.
Published	12/13/2024	Punch biopsy of skin.Most likely diagnosis?{{c1::Reiters syndrome (DDx: Bechets syndrome)}}.
Published	12/13/2024	What must always be thought about for cases of dermal melanoma (no in situ component identified)?{{c1::Metastatic or recurrent melanoma}}.
Published	12/13/2024	Desmoplastic melanoma is often positive for {{c1::SOX10}} and {{c1::S100}}, but negative for other melanocytic markers (immunohistochem…
Published	12/13/2024	Skin punch biopsy.Most likely diagnosis?{{c1::Cellular blue nevus}}.
Published	12/13/2024	Skin biopsy from the sun-exposed face of an elderly man.Most likely diagnosis?{{c1::Desmoplastic melanoma}}.
Published	12/13/2024	Shave of skin.Most likely diagnosis?{{c1::Eccrine poroma}}.
Published	12/13/2024	Key microscopic features of an ecrrine poroma inclide:1. {{c4::Acanthotic}} lesion connecting to the epidermis. 2. Resembles an {{c3::endophytic …
Published	12/13/2024	Skin excision.Most liekly diagnosis?{{c1::Trichoepithelioma}}.
Published	12/13/2024	Key microscopic features of a trichoepithelioma include:1. {{c1::Dermal}} tumor (skin location). 2. {{c2::Islands}} of {{c2::basaloid}}…
Published	12/13/2024	Trichoepitheliomas are associated with {{c1::Brooke Spiegler}} syndrome.
Published	12/13/2024	Key microscopic features of a spiroadenoma include:1. {{c1::Dermal}} tumour (skin location).2. "{{c2::Cannonballs}}" or {{c3::basophilic nodules}}.3. …
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Spiroadenoma}}.
Published	12/13/2024	Spiradenomas are associated with {{c1::Brooke Spiegler}} syndrome.
Published	12/13/2024	Skin punch biopsy.Most likely diagnosis?{{c1::Blue nevus}}.
Published	12/13/2024	Key microscopic features of a blue nevus include:1. {{c1::Bipolar spindled dendritic}} melanocytes in the {{c2::dermis}} (skin loc…
Published	12/13/2024	Skin punch biopsy.Most likely diagnosis?{{c1::Clark's dysplastic nevus}}.
Published	12/13/2024	Skin excision from the face of elderly individual.Most likely diagnosis?{{c1::Palisaded encapsulated neuroma}}.
Published	12/13/2024	Skin excision from an infant.Most likely diagnosis?{{c1::Infantile hemangioma}}.
Published	12/13/2024	Immunohistochemistry for {{c1::GLUT1}} (positive) can help make the diagnosis of infantile hemangioma due to the unique {{c1::placental…
Published	12/13/2024	Acral skin punch biopsy.Most likely diagnosis?{{c1::Cavernous hemangioma}}.
Published	12/13/2024	Key microscopic features of a cavernous hemangioma include:1. {{c2::Non-lobular}} (interface).2. Poorly demarcated proliferation of {{c1::large cystic…
Published	12/13/2024	The major difference between an acrospiroma and ecrrine poroma is that acrospiroma have {{c1::much deeper involvement}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Acrospiroma}}.
Published	12/13/2024	Immunohistochemistry for {{c1::CEA}} or {{c1::EMA}} can highlight the ducts of eccrine poromas.
Published	12/13/2024	Skin punch biopsy.Most likely diagnosis?{{c1::Actinic keratosis}}.
Published	12/13/2024	The risk of progression from actinic keratosis to squamous cell carcomina is ~{{c1::10}}-{{c1::20}}% per year.
Published	12/13/2024	Skin excision.Most likley diagnosis?{{c1::Pilar/Trichilemmal cyst}}.
Published	12/13/2024	Key microscopic features of a pilar/trichilemmal cyst include:1. Filled with {{c1::dense “wet” eosinophilic keratin}}.2. {{c2::Stratified sq…
Published	12/13/2024	Pilar/trichillemmal cysts most commonly occur on the {{c1::head/scalp}} and {{c1::neck}} (anatomical locations).
Published	12/13/2024	Skin excision. Most lilkely diagnosis?{{c1::Sebaceous carcinoma}}.
Published	12/13/2024	The most common anatomical site of sebaceous carcinomas is the {{c1::eyelids}}.
Published	12/13/2024	Sebaceous carcinomas have a strong association with {{c1::Muir-Torre syndrome}} (must consider if multiple).
Published	12/13/2024	Sebaceous hyperplasia presents clinically/grossly as a {{c1::yellow papule with central dimple}}.
Published	12/13/2024	Skin, shave biopsy.Most likely diagnosis?{{c1::Sebaceous hyperplasia}}.
Published	12/13/2024	Key microscopic features of a sebaceous hyperplasia include:1. {{c1::Lobules of sebocytes}} arranged around the {{c2::infundibulum of a cent…
Published	12/13/2024	Loss of {{c1::sebaceous glands}} is a critical microscopic feature for scarring alopecia.
Published	12/13/2024	Skin punch biopsy.Most likely diagnosis?{{c1::Leukocytoclastic vasculitis}}.
Published	12/13/2024	Leukocytoclastic vasculitis clinically presents as {{c1::non-blanching palpable purpura}} that has a predilection for the {{c2::lower l…
Published	12/13/2024	Key microscopic features of leukocytoclastic vasculitis include:1. {{c1::Fibrinoid}} necrosis of blood vessel walls.2. {{c2::Endothelial}} cell swelli…
Published	12/13/2024	Skin punch biopsy.Most likely diagnosis?{{c1::Erythema nodosum}}.
Published	12/13/2024	Key microscopic features of erythema nodosum include:1. {{c2::Septal panniculitis}} (most striking feature).2. {{c3::Thickening of fibrous septa, with…
Published	12/13/2024	Erythema nodosum most often presents as {{c1::red, tender nodules, on shins}}.
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Pemphigus vulgaris}}.
Published	12/13/2024	The most fundamental pathophysiology of pemphigous vulgaris is {{c1::autoantibodies}} directed against {{c1::desmoglein 3.}}
Published	12/13/2024	Key microscopic features of pemphigus vulgaris include:1. {{c3::Intraepidermal}} vesicle (location).2. Suprabasilar acantholysis with clefting and bli…
Published	12/13/2024	Skin biopsy.Most likely diagnosis?{{c1::Bullous pemphigoid}}.
Published	12/13/2024	The key microscopic feature of bullous pemphigoid is a {{c1::subepidermal cleft/blister}} with {{c2::abundant eosinophils}}.
Published	12/13/2024	Direct immunofluorescence analyis of bullous pemphigoid shows {{c1::linear}} deposition of {{c2::IgG}} and {{c2::C3}} at…
Published	12/13/2024	The fundamental pathology of bullous pemphigoid is autoantibodies to {{c1::BPAG1}} and {{c1::BPAG2}} on {{c1::hemidesmosomes}…
Published	12/13/2024	Skin gross finding.Most likely diagnosis?{{c1::Bullous pemphigoid}}.
Published	12/13/2024	The main differential for bullous pemphigoid is {{c1::epidermolysis bullosa acquisita}}.
Published	12/13/2024	Cylindromas are composed of 2 cell types:1. {{c2::Internal}} {{c1::squamoid}} cells (location, cell type).2. {{c2::Peripheral}} {{c1::basaloid}} cells…
Published	12/13/2024	Eccrine poromas are composed of 2 cell types:1. {{c1::Basaloid}} {{c2::poroma}} cells (appearence, cell type name).2. {{c1::Porous/squamoid}} {{c2::cu…
Published	12/13/2024	Skin shave biopsy.Most likely diagnosis? Differential?{{c1::Histoplasma capsulatum (DDx: Leishmaniasis)}}.
Published	12/13/2024	Key microscopic features of dermal histoplasmosis include:1. Evenly spaced {{c1::intracellular cysts (2-4 microns)}}.2. {{c2::Granulomatous}} inflamma…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Cutaneous myofibroma}}.
Published	12/13/2024	Key microscopic features of a cutaneous myofibroma include:1. Low power archictecture of {{c1::blue nodules}}.  2. {{c2::Spindle}}&nbsp…
Published	12/13/2024	Cutaneous myofibromas will have immunohistochemistry findings of:1. S100 = {{c1::negative}}.2. CD34 = {{c1::negative}}.3. Desmin = {{c1::negative}}.4.…
Published	12/13/2024	Skin shave.Most likely diagnosis?{{c1::Cryptococcus}}.
Published	12/13/2024	Key microscopic features of cutaneous cryptococcus include:1. {{c2::Acute}}, {{c2::giant cell}} and {{c2::granulomatous}} inflammation.2. ***Round {{c…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Kaposi sarcoma}}.
Published	12/13/2024	Key microscopic features of cutaneous {{c1::Kaposi sarcoma}} include:1. {{c2::Dermal}}-based lesion (location).2.  {{c3::Spindle}} cell…
Published	12/13/2024	Key microscopic features of cutaneous {{c1::dermatofibromasarcoma protuberans}} include:1. {{c2::Dermal}} location. 2. Cellular (cellularity…
Published	12/13/2024	Key immunohistochemistry findings to support the diagnosis of dermatofibrosarcoma protuberans includes:1. {{c1::CD34}} = {{c2::positive}}.2. {{c1::Fac…
Published	12/13/2024	If dermatofibrosarcoma protuberans loses its {{c2::storiform}} pattern and develops a {{c3::herringbone}}, one should consider malignan…
Published	12/13/2024	Shave of skin from the face.Most likely diagnosis?{{c1::Trichilemmoma}}.
Published	12/13/2024	Key microscopic features of a {{c7::trichilemmoma}} include:1. Almost exclusively occur on the {{c6::face}} (general anatomic location).2.&n…
Published	12/13/2024	A {{c2::papillary endothelial hyperplasia}} aka {{c3::Masson's}} tumor is a {{c1::benign}} {{c1::reactive}} process…
Published	12/13/2024	Skin nodule excision.Most likely diagnosis?{{c1::Papillary endothelial hyperplasia (Masson's tumor)}}.
Published	12/13/2024	Key microscopic features of {{c6::papillary endothelial hyperplasia (Masson's tumor)}} include:1. {{c2::Well-circumscribed}} (interface).2. …
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Dermatofibroma}}.
Published	12/13/2024	Immunohistochemistry findings supportive of a dermatofibroma include:1. Factor XIIIA = {{c1::positive}}.2. CD163 = {{c1::positive}}.3. CD68 = {{c1::po…
Published	12/13/2024	Key microscopic features of a {{c1::dermatofibroma}} include:1. {{c2::Dermal}}-based lesion (anatomical location).2. Proliferation of bland,…
Published	12/13/2024	Atypical fibroxanthomas are a {{c1::mesenchymal}} neoplasm of {{c1::no}} specific lineage differentation that typically occur in t…
Published	12/13/2024	Skin shave negative for HMWCK and melanocytic markers.Most likely diagnosis?{{c1::Atypical fibroxanthoma vs pleomorphic sarcoma (depending on depth)}}…
Published	12/13/2024	Key microscopic features of {{c1::pilomatrixoma}} include:1. {{c2::Well-circumscribed}} interface.2. Mixture of {{c3::basaloid}} and {{c3::s…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Pilomatrixoma}}.
Published	12/13/2024	{{c4::Pilomatrical carcinoma}} should be considered if a suspected pilomatrixoma has features of:1. {{c1::Infiltrative}} architecture.2. {{c2::Pr…
Published	12/13/2024	Key microscopic features of a {{c1::cylindroma}} include:1. {{c3::Dermal}} location.2. "{{c2::Jig-saw}}" architecture.3. {{c6::Nests}} of {{…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Cylindroma}}.
Published	12/13/2024	Sebaceous tumors are {{c1::ectopic}} sebaceous glands that are {{c1::not associated with hair follicles}} and include:1. {{c2::Seb…
Published	12/13/2024	Skin cyst excision.Most likely diagnosis?{{c1::Trichilemmal/pilar cyst}}.
Published	12/13/2024	Key microscopic features of a {{c4::trichilemmal/pilar cyst}} include:1. {{c2::Stratified squamous}} epithelium with {{c2::absent granular l…
Published	12/13/2024	Skin adnexal tumors can be anatomically categorized as:1. {{c1::Sebaceous}}.2. {{c1::Sweat gland/duct}}.3. {{c1::Hair follicle}}.
Published	12/13/2024	What simple differential should be thought of for epithelial neoplasm in the skin does NOT fit with a BCC, SCC, or SK?1. {{c1::Adnexal tumor}}.2. {{c1…
Published	12/13/2024	Excision of skin.Most likely diagnosis (what key feature is depicted by green arrows?)?{{c1::Trichoepithelioma (papillary mesenchymal bodies)}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Sebaceous adenoma (more basaloid cells and immature small sebocytes, than sebaceous hyperplasia)}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Sebaceoma (>50% basoloid cells)}}.
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Eccrine poromoa}}.
Published	12/13/2024	The {{c1::acrospiroma}} "family" of of sweat gland tumors are crudely differentiated by the following features which include:1. {{c2::Poroma…
Published	12/13/2024	Skin excision.Most likely diagnosis?{{c1::Inverted follicular keratosis}} ({{c2::benign}} tumor).
Published	12/13/2024	Key microscopic features of an {{c1::inverted follicular keratosis}} include:1. Low-power impression of a {{c2::seborrheic keratosis}}, but …
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