Notes in CBB25 enzyme inhibition

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Published	09/14/2024	There are special molecules that can interact with enzymes and suppress their activities. These molecules are called  {{c1::inhibitors}}.
Published	09/14/2024	Examples of drug enzyme-inhibitors include: {{c1::oMethotrexate}}, used in cancer chemotherapy -  inhibits DNA synthesis in malignant cells o{{c2…
Published	09/14/2024	What are the two major classes of enzyme inhibition?-{{c1::Reversible}} inhibition-characterized by rapid dissociation of enzyme-inhibitor complex.&nb…
Published	09/14/2024	Reversible inhibition--> competitive inhibition•Both the {{c1::substrate}} and {{c1::inhibitor}} compete for binding to the {{c2::active site}} of …
Published	09/14/2024	Reversible inhibition--> competitive inhibition--> example{{c2::Statin}}-   •a cholesterol reducing drug blocks de novo cholesterol synthes…
Published	09/14/2024	Reversible inhibition--> competitive inhibition--> example{{c1::Methotrexate}}- •An anticancer drug competitively inhibits the enzyme {{c2::dihy…
Published	09/14/2024	Reversible inhibition--> non-competitive inhibitiono Substrate and inhibitor binds to sites that are completely {{c1::separated}}. o Binding of inh…
Published	09/14/2024	Reversible inhibition--> non-competitive inhibition--> example{{c1::Allopurinol}}- •a noncompetitive inhibitor of {{c2::xanthine oxidase,}…
Published	09/14/2024	Reversible inhibition--> non-competitive inhibition--> exampleUse of ethanol is the treatment of methanol poisoningMethanol poisoning: oIngested…
Published	09/14/2024	Reversible inhibition--> uncompetitive inhibition-inhibitor binds to ES, creating ESI-Uncompetitive inhibition {{c1::CANNOT}} be overcome by increa…
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Published	09/14/2024	Irreversible inhibition--> exampleo{{c1::Penicillin}}  binds irreversibly to bacterial {{c2::transpeptidase}} enzyme, and thus suppress t…
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