Notes in 06_WBC

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Published	12/28/2023	What are the clinical and histologic features of mycosis fungoides?
Published	12/28/2023	Histology of nodular sclerosing lymphoma (a subtype of hodgkin lymphoma)?
Published	12/28/2023	Acute Myeloid Leukemia classically stains positively for which marker?
Published	12/28/2023	Which AML subtype is common in patients with Down syndrome who are under the age of 5?
Published	12/28/2023	Which AML subtype classically presents with gum infiltration? Does this subtype stain positive for MPO?
Published	12/28/2023	The t(15;17) translocation is characteristic to which leukemia subtype? What is the treatment?
Published	12/28/2023	What classic marker distinguishes Acute Lymphoblastic Leukemia from Acute Myelogenous Leukemia?
Published	12/28/2023	Which ALL subtype is more common, B or T cell? What cell surface markers distinguish the two?
Published	12/28/2023	In B-ALL, which common translocation is associated with a good prognosis? Which rarer translocation has a poor one?
Published	12/28/2023	When does T-ALL present? How does it present?
Published	12/28/2023	What is the characteristic pattern of cell-surface markers for Chronic Lymphocytic Leukemia (CLL)?
Published	12/28/2023	In what type of leukemia and lymphoma would you see a "smudge" cell?
Published	12/28/2023	What is the most common cause of death in patients with CLL?
Published	12/28/2023	What type of cell undergoes neoplastic proliferation to cause hairy cell leukemia?
Published	12/28/2023	What hematologic malignancy is characterisitically positive for tartrate-resistant acid phosphatase (TRAP)?
Published	12/28/2023	What are 2 common clinical features of hairy cell leukemia? What common feature of leukemia/lymphoma is not seen in HCL?
Published	12/28/2023	Where in the spleen do hairy cells accumulate in hairy cell leukemia?
Published	12/28/2023	What drug is the mainstay of treatment for Hairy Cell Leukemia? What is its mechanism?
Published	12/28/2023	What virus can lead to Adult T-Cell leukemia/lymphoma (ATLL)? What parts of the world is this virus seen in?
Published	12/28/2023	What hematologic malignancy typically presents with rash, generalized lymphadenopathy, and lytic (punched-out) bone lesions with hypercalcemia?
Published	12/28/2023	What malignancy clinically presents with lytic (punched-out) bone lesions (with hypercalcemia) in the absence of a rash?
Published	12/28/2023	Which two leukemias tend to present with a rash (representing cutaneous infiltration)?
Published	12/28/2023	What is a pautrier microabscess? What malignancy is is characteristic of?
Published	12/28/2023	How does Sezary syndrome occur? What does the characteristic cell look like?
Published	12/28/2023	What is significant about a t(9;22) translocation?
Published	12/28/2023	Which hematologic malignancies can carry the t(9;22) translocation?
Published	12/28/2023	A patient diagnosed with CML has splenomegaly, suggesting progression to accelerated form of the disease. What complications may shortly occur?
Published	12/28/2023	How do you distinguish CML from a leukemoid reaction?
Published	12/28/2023	What 3 myeloproliferative disorders are associated with JAK2 Kinase mutations?
Published	12/28/2023	What is the most common venous thrombosis that can arise in patients w/ polycythemia vera?
Published	12/28/2023	What is the treatment for CML?
Published	12/28/2023	Why do polycythemia vera patients get itchy after bathing?
Published	12/28/2023	How do you distinguish polycythemia vera from reactive polycythemia?
Published	12/28/2023	What tumor characteristically produces EPO, leading to a reactive polycythemia?
Published	12/28/2023	What are the 3 key clinical features of myelofibrosis?
Published	12/28/2023	In a case of infectious mononucleosis, which part of the lymph node and which part of the spleen become hyperplastic?
Published	12/28/2023	When would you see follicular hyperplasia of the lymph node?
Published	12/28/2023	What malignancy is associated with a t(14;18) translocation?
Published	12/28/2023	How does the translocation t(14;18) meaningfully alter protein expression?
Published	12/28/2023	What is the mainstay of treatment for follicular lymphoma?
Published	12/28/2023	How do you distinguish follicular lymphoma from reactive follicular hyperplasia?
Published	12/28/2023	What malignancy proliferates in the mantle zone of a lymph node? Where is the mantle zone of a lymph node?
Published	12/28/2023	The t(11:14) translocation is characteristic of which hemotologic malignancy? How does this translocation drive the malignancy?
Published	12/28/2023	What type of lymphoma is classically associated with chronic inflammatory states like: Hashimoto thyroiditis, Sjögren syndrome, and H. pylori gastriti…
Published	12/28/2023	Where in the body does the African form of Burkitt lymphoma arise? What about the sporadic form?
Published	12/28/2023	The t(8;14) translocation is characteristic of which hematologic malignancy? How does this translocation alter protein expression?
Published	12/28/2023	What malignancy demonstrates a classic "starry-sky appearance" on histology?
Published	12/28/2023	What is the most common form of Non-Hodgkin lymphoma?
Published	12/28/2023	What cell is know for its "owl-eye nuclei"? What disease is it pathognomonic for? What cell surface receptors does it express?
Published	12/28/2023	What is a lacunar cell?
Published	12/28/2023	Which subtype of hodgkin lymphoma has the best prognosis?
Published	12/28/2023	How do the neoplastic cells in multiple myeloma induce the formation of lytic bone lesions?
Published	12/28/2023	What type of protein is excreted in the urine in patients with multiple myeloma?
Published	12/28/2023	What immunoglobulins can cause an M-spike on serum protein electrophoresis (SPEP) in multiple myeloma?
Published	12/28/2023	What are the 3 fates of the free light chain that is produced in multiple myeloma?
Published	12/28/2023	What is MGUS?
Published	12/28/2023	In which type of disease do you see Birbeck (tennis racket) granules on electron microscopy? What are the surface markers are associated with them?
Published	12/28/2023	An IgM-derived M-spike on serum protein electrophoresis is indicative of what hematologic malignancy?
Published	12/28/2023	The visual and neurologic deficits seen in Waldenström macroglobulinemia have what etiology?
Published	12/28/2023	How is Waldenström Macroglobulinemia treated?
Published	12/28/2023	What three diseases comprise langerhans cell histiocytosis?
Published	12/28/2023	What cell surface marker is classically present in DLBCL? From what malignancy does DLBCL typically arise?
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