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G31 Circulatory System Development
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11/02/2024
{{c1::Ventricular septal defect}} is the most common congenital heart defect.
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Genetic risk factors for congenital heart defect include {{c1::holt oram syndrome (TBX5 deficiency)}} and {{c1::trisomy 21}}.
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teratogens that can cause congenital heart defects (4)
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{{c1::Rubella::infectious}} and {{c1::gestational diabetes::metabolic}} are two common causes of congenital heart defects.
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how do embryos receive nourishment in the first two weeks of life
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when does the embryonic cardiovascular system begin to develop
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neural crest contribution to the developing cardiovascular system
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sources of vasculogenesis
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extraembyronic mesoderm contributions to vasculature
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contributions of intraembryonic splanchnic mesoderm to CV system
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when does vasculogenesis occur and in what locations initially
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describe the process of vasculogenesis
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{{c1::Vasculogenesis}} refers to the de novo synthesis of new blood vessels within a matrix of dense mesenchyme, whereas, {{c1::angiogenesis}} refers …
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The corporal/systemic embryo is initially supplied by {{c1::paired dorsal aortae}} and drained by {{c1::the anterior (cranial/preaxial), posterio…
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The primary extraembryonic blood vessels are the following:{{c1::Vitelline arteries}}, {{c1::vitelline veins}}, {{c1::umbilical arteries}} (paired){{c…
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when are the four chambers and valves of the heart complete?
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where does the cardiogeneic area form
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when do the endocardial tubes form?
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what happens to the cardiogenic region during embryo folding
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fusion of the endocardial tubes forms what?
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what does the myocardium secrete within the heart tube
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function of myocardial cells in primitive heart tube blood flow
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order of blood flow through primitive heart tube
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The sinus vensosus is a {{c1::two}}-horned structure that drains the {{c1::vitelline}}, {{c1::cardinal}}, and {{c1::umbilical}} veins
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The primitive ventricle becomes the primitive left ventricle after it first {{c1::develops trabeculae carneae}}.
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what does the primitive constriction between the primitive atrium and primtive ventricle form
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The {{c1::atrioventricular canal}} is the internal channel between the primitive atrium and ventricle.
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segments of the bulbis cordis
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The truncus arteriosus gives rise to the {{c1::right and left aortic arches}} which flow into {{c1::their ipsilateral dorsal aortae}}
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artery and venous parts of the heart tube
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Cardiac looping begins during week {{c1::4}} of embryonic development
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In cardiac looping, the {{c1::venous::arterial/venous}} end of the heart tube is pulled {{c1::dorsally}} and {{c1::cranially}} to the {{c1::arterial::…
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what happens to the undivided AV canal during septation of the heart (motion-wise)
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Heart valve formation in embyrology
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what happens to the sinus venosus during definitive right atrium formation
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Remnants of the primitive atria form {{c1::the pectinate muscles (rough surface)}} of the adult atria
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During the formation of the definitive left atrium, the {{c1::primitive pulmonary vein}} gives rise to the smooth parts of the left atrium through {{c…
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Atrial septa typically first begin to form during week {{c1::5}} of embryonic development
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The initial large opening between primitive atria is called the {{c1::foramen primum/ostium primum}}.
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The foramen primum is occluded by the septum {{c1::primum}} as it grows from the roof of the primitive atrium towards the endocardial cushions
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As the formen primum is closed, fenestrations begin to appear in the septum {{c1::primum}}, forming the {{c1::foramen secundum}}
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The septum secundum protudes from the posterior atrial wall, occluding the foramen {{c1::secundum}} completely except for a small {{c1::displaced open…
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what closes the foramen oval
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clinical manifestations of atrial septal defects
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is a patent foramen oval concerning
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The {{c2::primitive ventricle}} forms the {{c1::definitive L ventricle}}.The {{c1::definitive right ventricle}} derives from {{c2::the caudal par…
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When does the interventricular septum appear and what does it present as during development?
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In the first step of the interventricular partitioning, the {{c1::muscular}} interventricular septum is formed by the {{c1::cranial}} growth of the {{…
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The {{c1::conus cordis (cranial portion of the bulbus cordis)}} gives rise to the smooth outflow tracks of both ventricles
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What divides both the truncus arteriosus and the conus cordis?{{c1::The aorticopulmonary/spiral/truncoconal septum.}}
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Neural crest cells migrate into the paired {{c1::truncal}} ridges and {{c1::bulbar}} ridges in the walls of the truncus ateriosus and conus cordi…
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The aorticopulmonary septum grows {{c1::caudally::directionality}}.
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Eventually, the aorticopulmonary/spiral septum divides the {{c1::truncus arteriosus::superiorly}} into the {{c1::ascending aorta and pulmonary trunk}}…
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During formation of the great vessels, {{c1::neural crest cells}} invade the conus cordis and truncus arteriosus.
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The aorticopulmonary septum eventually fuses {{c1::with the muscular interventricular septum, forming the membranous part of the interventricular sept…
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How are the aortic and pulmonic valves separated during embryonic development?{{c1::The aorticopulmonary septum bisects the 4-cusp valve of the truncu…
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Ventricular septal defects are frequently caused by defects in {{c1::the membranous part of the interventricular septum}}. These defects occur due to …
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What is the primary consequence of ventricular septal defects?{{c1::Oxygenated blood from the left ventricle is shunted to the right ventricle. This r…
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What is the etiology and outcome of non-persistent ventricular septal defects?{{c1::An error in formation of the muscular part of the interventricular…
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{{c1::Persistent truncus arteriosus}} is a congenital anomaly caused by {{c2::the failure of the aorticopulmonary septum to develop}}.
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Impaired division of the truncus arteriosus and conus cordis results in:{{c1::Superior ventricular septal defect.A singular outflow tract that shared …
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What causes transposition of the great vessels (aorta and pulmonary trunk)?{{c1::The aorticopulmonary septum descends linearly instead of spiraling. T…
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Transposition of the great vessels is lethal unless {{c1::an interventricular defect is present or the ductus arteriosus is patent}}.Ot…
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What heart defects are characteristic of tetralogy of fallot?Best remembered with the {{c1::PROVe}} mnuemonic.{{c1::Pulmonary trunk stenosisRight vent…
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Tetralogy of Fallot {{c1::is::is/is not}} compatible with life.
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What is the primary cause of tetralogy of fallot?{{c1::An unequal distrubution of the outflow tracts within the truncus arteriosus and conus cordus.}}
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The descending aorta is formed embryologically from {{c1::the paired dorsal aortae::structure}}.
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The paired vitelline arteries of the yolk sac form the adult {{c1::celiac trunk}} and {{c1::superior mesenteric artery}} which supply the {{c1::foregu…
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The paired umbilical arteries of the placenta give rise to the {{c1::singular inferior mesenteric artery}} and the {{c1::superior vesicle arteries}} t…
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{{c1::Six}} pairs of arteries, called aortic arches, arise from {{c1::the truncus arteriosus}} and connect to the {{c1::ipsilateral::ipsilateral/contr…
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Aortic arches are each associated with paired {{c1::pharyngeal arches}} and supply structures of the head.The vast majority of them {{c1::regress/invo…
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The vessels that form from the embryological aortic arches include the following:{{c1::Aortic archR/L common carotid aa.R/L subclavian aa.The brachioc…
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In addition to the great arteries, the {{c1::ductus arteriosus}} also arises from one of the embryonic aortic arches
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At birth, the ductus arteriosus {{c1::constricts and fills with connective tissue}}. It is then termed the {{c1::ligamentum arteriosum}}.
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What causes the left recurrent laryngeal nerve to descend lower than the right during embryological development?{{c1::Due to differential regression o…
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What congenital anomalies are the result of the failure of the right dorsal aorta to degenerate?{{c1::double aortic arch (aortic ring)retroesophageal …
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What are the primary complications of an aortic ring?{{c1::Constriction of the trachea and esophagus}}
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What other congenital anomaly besides an aortic ring can cause dsyphagia? What causes this?{{c1::A retroesophageal right subclavian artery}}
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11/02/2024
What is not formed in a retroesophageal R subclavian artery anomaly?{{c1::The brachiocephalic trunk.}}
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Fetal blood bypasses the liver via the {{c1::ductus venosus}}.This shunt connects the {{c1::umbilical vein}} to the {{c1::inferior vena cava}}.
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Blood is incapable of entering the fetal lungs due to {{c1::the presence of fluid in the lungs}}. It is instead shunted to the {{c1::aorta}} through t…
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Fetal segmental oxygenation patterns are far different from adult oxygenation patterns.In the fetus, highly oxygenated blood can be found in the {{c1:…
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In the fetal heart, blood in the left side of the heart is {{c1::highly}} oxygenated. Blood in the right side of the heart is {{c1::moderately }}…
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What causes the foramen ovale to shut?{{c1::Fluid is drained from the lungs and the pressure in the pulmonary circuit drops. This greatly diminishes t…
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Full closure of the ductus arteriosus can take anwhere between {{c1::8 weeks and one year after birth}}.
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The ductus venosus collapses {{c1::7 days}} after birth and forms {{c1::the ligamentum venosum}}.
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At birth, the distal umbilical arteries {{c1::constrict and become fibrotic}}. Proximal to the body trunk, this creates {{c1::the medial umbilica…
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At birth, the umbilical {{c2::vein}} collapses and form the {{c1::round ligament of the liver (ligamentum teres hepatis)}}. This structure can be obse…
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11/02/2024
Primary clinical consequences of a patent ductus arteriosus{{c1::Pulmonary hypertension and cardiac hypertrophy, some degree of lower extremity hypope…
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