Notes in Exocrine pancreas

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Status	Last Update	Fields
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.1 \| Anatomy \| Briefly outline clinically relevant aspects of pancreas anatomy
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.2.1 \| Pathologic classification \| Provide a classification for pancreatic neoplasms
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.6.2 \| Pre-malignant lesions \| IPMN \| Provide a brief overview of indraductal papillary mucinous neoplasms (IPMNs) of the …
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.3 \| Epidemiology \| Describe the epidemiology of pancreatic ductal adenocarcinoma
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.4.1 \| Aetiology and risk factors \| List the major risk factors for exocrine pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.4.2 \| Aetiology and risk factors \| Familial risk factors \| Provide more detail on familial risk factors for pancreatic ca…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.4.3 \| Aetiology and risk factors \| Genetic testing \| Who should be referred for genetic testing
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.4.4 \| Screening \| Who should be undergo screening for pancreatic cancer and how should this be performed
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.5 \| Molecular pathogenesis \| Briefly describe the molecular pathogenesis of exocrine pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.6.1 \| Pre-malignant lesions \| PanIN \| Briefly describe pancreatic intraepithelial neoplasia (PanIN)
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.6.3 \| Pre-malignant lesions \| MCNs \| Provide a brief overview of mucinous cystic neoplasms (MCNs)
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.6 \| Premalignant lesions \| List the three lesions considered to be precursor lesions of pancreatic adenocarcinoma
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.7 \| Histopathology \| Briefly describe the macroscopic and microscopic (incl. IHC) appearance of pancreatic ductal adenoca…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.8 \| Grade \| Briefly describe the grading systems used in pancreatic ductal adenocarcinoma
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.9 \| Biologic behaviour (natural history) \| Briefly describe the biologic behaviour of pancreatic ductal adenocarcinoma
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.1 \| Clinical presentation \| Describe the clinical presentation of pancreatic ductal adenocarcinoma
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.2.1 \| Differential diagnosis \| Jaundice \| Provide a differential diagnosis and classification for jaundice
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.2.2 \| Differential diagnosis \| Pancreatic mass \| Give a brief differential diagnosis for a pancreatic mass identified on …
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.3 \| Workup \| Describe your workup for suspected exocrine pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.4 \| Imaging appearance \| Briefly describe the appearance of pancreatic cancer on abdominal ultrasound, CT, ERCP and MRI
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.5.1 \| Staging \| Describe the AJCC 8th edition staging of pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.5.2 \| Staging \| Outline the key differences between the AJCC 7th and 8th editions for the staging of pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.7.1 \| Prognosis \| Briefly outline the prognosis for exocrine pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.6 \| Resectability \| Discuss the concepts and definitions of resectable, borderline resectable and unresectable pancreatic…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.1 \| Management \| Overview \| Provide an overview of the management of pancreatic adenocarcinoma
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 2.7.2 \| Prognostic factors \| List prognostic factors for pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.1 \| Management \| Resectable \| Surgery \| Briefly describe the principles of surgery for resectable / borderline resectab…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 1.2.2 \| Pathologic classification \| Acinar carcinoma \| Briefly describe the prognostic significance and management implicat…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.2 \| Resectable \| Adjuvant chemotherapy \| Briefly describe the indications, timing, duration and recommended regimens fo…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.4.1 \| Resectable \| Adjuvant chemoradiotherapy \| Discuss the rationale for both adjuvant approaches that include and tho…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.5.1 \| Borderline resectable \| Neoadjuvant therapy \| Discuss the indications, rationale and protocol for neoadjuvant the…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.5.2 \| Borderline resectable \| Neoadjuvant therapy \| Discuss the evidence for neoadjuvant therapy in potentially resecta…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.3.1 \| Resectable \| Adjuvant chemotherapy \| Briefly describe the clinical trials that have demonstrated the benefit of a…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.3.2 \| Resectable \| Adjuvant chemotherapy \| Choice of regimen \| Briefly describe the trials guiding the choice of adjuva…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.4.2 \| Resectable \| Adjuvant chemoradiotherapy \| Briefly describe the trials assessing the benefit of adjuvant chemoradi…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.6.1 \| Locally advanced \| Overview \| Provide a brief summary of the management of locally advanced pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.6.2 \| Locally advanced \| FOLFIRINOX \| Discuss the rationale and evidence for the use of FOLFIRINOX as upfront treatment…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.6.3 \| Locally advanced \| Chemoradiotherapy \| Discuss the use of chemoradiotherapy in the management of locally advanced…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.6.4 \| Locally advanced \| SBRT \| Discuss the role of SBRT in the management of locally advanced pancreatic cancer (LAPC)
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.2.6.5 \| Locally advanced \| SBRT \| Discuss the role of SBRT in the management of locally advanced pancreatic cancer (LAPC)
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.4 \| Symptom management \| Briefly describe approrpiate management options for the following common symptomatic problems in…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 3.3.1 \| Metastatic disease \| Briefly outline the first-line management of metastatic pancreatic cancer
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 4.1 \| Treatment technique \| Describe your technique for neoadjuvant chemoradiotherapy for borderline resectable /locally ad…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 5.1 \| Follow up \| Describe your follow up plan following treatment of resectable/borderline resectable / locally advanced p…
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 6.1 \| Local recurrence \| Briefly discuss the management of locally-recurrent pancreatic cancer following resection
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 7.1 \| Clinical trials \| Span-C \| Briefly describe the Span-C clinical trial open at RNSH
Published	02/18/2024	GI \| Pancreas \| Exocrine \| 7.2 \| Clinical trials \| MASTERPLAN \| Briefly describe the MASTERPLAN clinical trial
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